Effects of Nolvadex
For a breast cancer patient, the action of Nolvadex is very simple. By blocking the estrogen hormone compound, cancer cannot nourish the hormone it needs to survive. Although effective, it is not always the only compound used, or even the first. Aromatase inhibitors (AIs) are often used early because they have the ability to reduce serum estrogen levels. Over time, there will be a transition from AI to a SERM like Nolvadex. As a preventative measure, people with a strong family history of breast cancer can prevent it by using Nolvadex at an early stage.
For users of anabolic steroids, the main effect of Nolvadex on the course is to prevent gynecomastia. Nolvadex does not appear to have a strong effect on preventing the other major estrogenic effect associated with fluid retention, but it can often be controlled by other means. When it comes to gynecological protection, this can be enough for many men and should be your first choice if it can get the job done. Otherwise, use an AI such as Arimidex (Anastrozole) or Femara (Letrozole). However, AIs can negatively affect cholesterol. AIs alone do not appear to have a strong negative effect, but when combined with flavoring steroids, this effect appears to be irritating. Cholesterol can be controlled with AI, but if it can do its job, a SERM like Nolvadex should be your first choice.
The end effect of Nolvadex is most valuable to the user of anabolic steroids. The use of anabolic steroids suppresses the natural production of testosterone. The rate of suppression will depend on the steroids used, but in most cases it will be significant. Once the use of anabolic steroids has ceased, provided the person has not suffered from a previous condition of low testosterone and has not damaged their hypothalamic-pituitary-ovarian axis (HPTA) due to poor practice, the natural production of testosterone will start again.This natural production starts by itself, but there is a problem.
When you are out of a cycle, your natural testosterone levels will be extremely low and even if production resumes, they will remain low for a very long time. It will take months and months for the body to fully recover its previously high levels of natural testosterone. In fact, it can take up to a year or more depending on the severity of the cycle and the person’s general dispositions. This means that a person will be in a state of low testosterone for some time, which may be accompanied by many unpleasant symptoms.
This condition can include all the symptoms associated with low testosterone. In addition, a person with low testosterone levels can lose a lot of muscle tissue gained through the use of steroids, as cortisol becomes the dominant hormone in the body. This means that a person will be in a state of low testosterone for some time, which may be accompanied by many unpleasant symptoms.
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Side effects of Nolvadex
There are possible side effects of Nolvadex, but we will find that it is a very well tolerated SERM for most men and women. However, side effects are possible, but usually they occur very rarely. Most men do not want the first problem. Nolvadex side effects will be slightly more common in women, but even then they are not as common.
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Possible side effects of using Nolvadex include:
- Vaginal itching, bleeding, discharge or discomfort
- Stomach ache
The above are the most common side effects of Nolvadex. Other possible side effects of Nolvadex, although less common than those listed above, include:
- Decreased white blood cell count
- endometrial changes
- High triglycerides
- Pulmonary embolism
As for Nolvadex side effects, that’s all there is to it. Sure, some of these effects do not sound as pleasant, but again, most Nolvadex side effects are quite rare. In conclusion, women who are pregnant or may become pregnant should not take Nolvadex for any reason. Such use can potentially be very harmful to the developing child.
Contraindications of Nolvadex
Nolvadex is not used:
- if you are allergic to the active substance;
- with intolerance to auxiliary components;
- with severe thrombocytopenia;
- with leukopenia;
- with hypercalcemia;
- during pregnancy;
- when breastfeeding.
A number of women taking Nolvadex for the treatment of premenopausal breast cancer experience a lack of menstruation.
The use of Nolvadex in combination with coumarin-type anticoagulants may lead to a significant increase in the anticoagulant effect. In cases of concomitant use of these drugs, it is recommended to monitor the patient carefully.
When Nolvadex is used in combination with cytotoxic agents, there is an increased risk of thromboembolic events. An increase in cases of endometrial changes, including hyperplasia, polyps and cancer, has been noted with Nolvadex treatment. The frequency and pattern of this increase suggest that the underlying mechanism is related to the estrogenic properties of Nolvadex. All patients taking or taking Nolvadex who have abnormal vaginal bleeding should be examined in a timely manner.
During clinical trials performed after treatment of breast cancer patients with tamoxifen, a number of secondary primary tumors have been observed that occur elsewhere than in the enometrium and the opposite breast. A causal relationship has not been established and the clinical significance of these observations remains uncertain.